Professor, Translational Science and Therapeutics Division

Medical Director, Cellular Immunotherapy and the Bezos Family Immunotherapy Clinic

Leonard and Norma Klorfine Endowed Chair for Clinical Research

      Fred Hutchinson Cancer Center

Professor of Medicine, Division of Medical Oncology

            University of Washington

Seattle, Washington, USA

David G. Maloney, MD, PhD received his MD and PhD in cancer biology from Stanford University, completed his internship and residency in internal medicine at Brigham and Woman’s Hospital, and a fellowship in oncology at Stanford. He joined the faculties of Fred Hutchinson Cancer Center and the University of Washington in 1994.

Dr. Maloney’s research interest is in the development of immunotherapies for lymphoma, myeloma, CLL, and ALL. He has had a long-standing interest in the mechanisms of action of monoclonal antibodies and the use of non-myeloablative allogeneic transplantation for the treatment of hematologic malignancies. Non-myeloablative conditioning has enabled many more patients to take advantage of the lifesaving potential of stem cell transplantation.

For much of his career, Dr. Maloney has focused on developing and improving antibody-based therapies against blood cancers. He was instrumental in the development and testing of rituximab while working with Dr. Ron Levy at Stanford. Rituximab was the first antibody-based cancer drug on the market, and it has transformed treatment of certain leukemias and lymphomas.

Currently, Dr. Maloney’s major interests are in the development of chimeric antigen receptor (CAR) T-cell therapy, for which he leads multiple clinical trials using this therapy for a variety of cancers.

Dr. Maloney has amassed greater than 275 publications in peer-reviewed journals in the areas of research described above. In 1993, the Society for Biological Therapy (now the Society for Immunotherapy of Cancer) conferred on Dr. Maloney its Presidential Award. His care and commitment to patients is routinely acknowledged, most recently over the last five years when Dr. Maloney was included in Newsweek’s Top Cancer Doctors, the Castle Connolly Guide, America’s Top Doctors® for Cancer and named by his peers as a Top Doctor in Medical Oncology, Seattle Magazine, as recently as 2022.