Management of breast cancer is rapidly evolving. A number of potentially practice-changing abstracts are expected to be presented during the 2021 San Antonio Breast Cancer Symposium (SABCS 2021) in December, 2021. This webcast of the in-person oncology conference held in Seattle, Highlights from SABCS 2021, expert faculty will place abstract findings from the SABCS 2021 annual meeting into clinical context and discuss how the results may change the current standard of care for breast cancer patients.